# RMP-RESP-005 Scheduled breathing rate and oxygen saturation (SpO2) checks: reminder, preparation checklist, readings as displayed and a breathing rate counted by the CMO
# Version 0.2 (Draft). CONCEPTUAL. NOT FOR CLINICAL USE.
# Space Medicine Foundation robot-readable protocol library. Format: https://spacemedicinefoundation.org/robotic-medicine/protocols/schema/
# Every threshold marked <set by ...> must be set by the named owner (see the schema) before any use.
schema_version: '0.3'
version: '0.2'
status: draft
conceptual: true
not_for_clinical_use: true
max_autonomy: 2
missions:
- leo
- commercial
- moon
- mars
updated: '2026-10-21'
review:
  state: reviewed-ai-assisted
  requested: '2026-10-21'
  reviewed: '2026-10-21'
  human_clinician_review: false
  text: >-
    AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 11 review:
    10 required corrections, R1 to R10; 9 optional suggestions not applied in this version); all required
    corrections that apply to this protocol are applied in this version (see Corrections). No named human
    clinician has reviewed it. Not for clinical use.
fixed_rules:
  flight_surgeon_is_medical_authority: true
  cmo_acts_under_delegated_care: true
  human_starts_and_restarts_robot: true
  robot_never_diagnoses: true
  no_drug_or_fluid_advice_by_robot: true
  safe_state_on_fault_or_no_response: true
  lost_link_pause_then_cmo_decides: true
robot_lockouts:
  diagnosis: true
  drug_or_fluid_advice: true
  starting_stopping_or_adjusting_oxygen_or_any_medicine: true
  self_start_or_self_restart: true
  changing_own_protocol_thresholds_or_limits: true
  handing_over_a_mismatched_item_as_verified: true
id: RMP-RESP-005
slug: rmp-resp-005
title: >-
  Scheduled breathing rate and oxygen saturation (SpO2) checks: reminder, preparation checklist, readings
  as displayed and a breathing rate counted by the CMO
category: resp
tier: 3
rung_note: >-
  Max rung 2 for the scheduled prompt, a checked kit fetch, showing the oximeter preparation checklist,
  recording oxygen saturation (SpO2) and heart rate as displayed, and recording the breathing rate the
  CMO counts and states. The crewmember places the oximeter; the robot never counts breaths from video
  and never touches anyone.
result_language:
  use:
  - reading as displayed
  - saturation not obtained
  - breathing rate as counted by the CMO
  - logged, not interpreted
  - sent to flight surgeon
  never:
  - normal
  - no problem found
  - all clear
  - negative
  - any diagnosis or cause
  - high
  - low
  - in range
  - out of range
  - good
  - healthy
  - stable
  - better
  - worse
  - reading is reassuring
  - probe error
  - safe
  - mild
  - minor
scope:
  summary: >-
    At the times the flight surgeon schedules, the robot prompts the crewmember that a breathing check
    is due; the check starts only when the crewmember or the CMO accepts. The robot brings the oximeter
    by a checked kit fetch and shows the preparation checklist; the crewmember places the pulse oximeter.
    The robot records oxygen saturation (SpO2, the percentage of oxygen-carrying blood) and heart rate
    as displayed once the reading has stopped changing, and the breathing rate the CMO counts over one
    full minute on their own timer and states. A failed oximeter reading is URGENT.
  why: >-
    A raised breathing rate is "a powerful sign of acute illness and distress", and an extreme value in
    a single measure needs urgent review (NEWS2, 2017), so the breathing rate is counted by a human over
    a full minute and recorded as stated; the alert values are the clinical lead's (design judgment).
    A pulse oximeter reads best with a warm, relaxed hand below heart level, no nail polish, the person
    still, and a reading taken once it stops changing; circulation, skin pigmentation, thickness and temperature
    can affect it (FDA 2025). A failed reading is never reassuring: it can mean poor circulation, so it
    is URGENT, as in the other protocols that use the oximeter. The shared value SPO2_ALERT_PCT only raises
    an alert; it never gates a crew action (the crew act without waiting for a reading), and the clinical
    lead sets it per mission with the flight surgeon, because the cabin atmosphere can differ by mission.
  covers:
  - Scheduled breathing rate and SpO2 checks on the flight surgeon's schedule
  - 'Breathing trouble: RMP-RESP-001; cabin air alarms: the commander''s procedure'
  - 'Heart rate and blood pressure checks: RMP-CARD-005'
  locked_out:
  - Diagnosis or naming a cause
  - Any medicine, fluid or oxygen advice; starting, stopping or adjusting oxygen
  - Touching the crewmember
  - >-
    Handing over any medicine outside RMP-PHARM-001, or after a MISMATCH or CANNOT VERIFY (the item stays
    quarantined; only the CMO can ask for it, through the RMP-PHARM-001 logged two-step override)
  - Placing or removing the oximeter, or touching anyone
  - Counting breaths from video or sound, or estimating a breathing rate
  - Saying whether a reading is normal, high, low or changed
  - Changing the schedule or the alert values
  related:
  - RMP-RESP-001
  - RMP-RESP-004
  - RMP-CARD-005
  - RMP-PREV-002
  - RMP-INF-001
  - RMP-EVA-001
roles:
  medical_authority: Flight surgeon (ground). Holds medical authority for every run.
  onboard_lead: >-
    Crew medical officer (CMO), acting under delegated care; uses the pre-approved onboard checklist when
    there is no link.
  others:
  - 'Second trained CMO: receives every alert and takes over if the CMO is the patient'
  - 'Vehicle commander: leads any cabin emergency procedure'
  - 'Other crew: help as the CMO or commander directs'
  robot_may:
  - Prompt the crewmember at the scheduled time
  - Bring the oximeter by a checked kit fetch (or an emergency fetch)
  - Show the preparation checklist
  - Record SpO2 and heart rate as displayed and the breathing rate as the CMO states it
  - Send the record to the flight surgeon
  robot_may_not:
  - Place the oximeter or touch anyone
  - Count breaths itself or estimate a rate
  - Say what a reading means
  - Start a scheduled check without a human accepting the prompt
  commercial: >-
    On commercial flights, 'flight surgeon' and 'CMO' mean the operator's designated medical authority
    and trained onboard responder. If no trained responder is aboard, this protocol is not used. (NASA-STD-3001
    requires two CMOs per vehicle for NASA programs [V1 3006]; FAA rules set no medical standards for
    spaceflight participants.)
preconditions:
- id: PRE-1
  text: >-
    The check starts only when the crewmember (or the CMO) accepts the on-screen prompt; a loaded schedule
    alone never starts it. An unaccepted prompt is logged "not accepted" and the CMO is told. A crewmember
    or the CMO can also start it by command.
  check: human_start == true
  refs:
  - V2 10174
- id: PRE-2
  text: Robot self-test passed; kit stowage locations known.
  refs:
  - V2 10161
  - V2 7059
- id: PRE-3
  text: Robot and supplies restrained when not moving.
  refs:
  - V2 7046
- id: PRE-4
  text: Link status known. The crew never wait for the robot before acting.
  check: link_state in [live, delayed, down]
consent:
  standard: The crewmember agrees to the check and to readings being recorded and sent to the flight surgeon.
  emergency: >-
    If the crewmember cannot agree, this is not a scheduled check: the robot sends an URGENT alert and
    a crewmember checks in person (X7).
  withdrawal: The crewmember can stop at any time; a stopped check is logged as "stopped", never as a
    value.
inputs:
- id: IN-1
  name: >-
    The flight surgeon's schedule and the clinical lead's alert values (SpO2 uses the shared parameter
    SPO2_ALERT_PCT)
  source: Flight surgeon / clinical lead
  required: true
  if_missing: The robot shows "schedule not loaded" and runs only on a human command.
- id: IN-2
  name: SpO2 and heart rate as displayed by the crew-placed pulse oximeter, after the reading stops changing
  source: Crew-placed pulse oximeter
  required: true
  if_missing: Log "saturation not obtained" (never a value); RF2 applies.
- id: IN-3
  name: Breathing rate as counted by the CMO over one full minute and stated
  source: CMO
  required: true
  if_missing: Log "breathing rate not stated" (never a value); the CMO is told.
- id: IN-4
  name: Air or supplemental oxygen in use (flow and device), as stated by the CMO, with the clock time
  source: CMO (as stated)
  required: true
  if_missing: Log "oxygen in use not stated"; never a value. The robot never starts, stops or adjusts
    oxygen.
- id: IN-5
  name: Symptoms in the crewmember's words (breathlessness, cough, chest pain, feeling faint, fever)
  source: Crewmember
  required: false
  if_missing: Log "no response"; D3 applies.
- id: IN-6
  name: Link status and delay
  source: Communications system
  required: true
  if_missing: Treat as link down; the record is queued.
steps:
- id: S1
  actor: robot
  rung: 2
  action: >-
    At the scheduled time, show the crewmember an on-screen prompt that a breathing check is due, and
    tell the CMO (URGENT if any red flag is stated). The check starts only when the crewmember or the
    CMO accepts the prompt; an unaccepted prompt is logged "not accepted" and the CMO is told. Every URGENT
    alert goes to the CMO and the flight surgeon at the same time (queued for the flight surgeon if the
    link is down). If the CMO is the patient, is busy treating, or does not answer, the alert goes to
    the second trained CMO, or the crewmember named before flight [V1 3006]. An URGENT alert that is not
    acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember.
  success: Prompt accepted, or "not accepted" logged.
  refs:
  - V2 10174
  - V1 3003
  - V1 3006
- id: S2
  actor: robot
  rung: 2
  action: >-
    On the CMO's command, run a checked kit fetch of the vital-signs kit (pulse oximeter): check the kit
    ID and seal before hand-over, and quarantine a kit whose ID or seal does not match (no hand-over;
    the CMO is told). Any medicine goes only through RMP-PHARM-001. If an URGENT red flag has fired or
    a human states an emergency, bring it instead as an emergency fetch: This is an emergency fetch on
    a human command (CMO): no barcode check runs before hand-over and nothing waits for one. The robot
    reads the kit's own label and seal status only if that adds no delay, says "EMERGENCY FETCH – NOT
    VERIFIED (CMO command)", and "seal not intact" if so, and hands the kit over anyway. The fetch is
    logged as an override: time, who asked, the reason as stated, kit ID and seal status. It never says
    "verified".
  success: Kit within reach after a matched ID and seal, or quarantined, or emergency fetch logged.
  limit: <set by validation>
  refs:
  - V2 7046
  - V2 7059
- id: S3
  actor: robot
  rung: 2
  action: >-
    Show the oximeter preparation checklist: hand warm and relaxed, held below heart level and restrained;
    no nail polish on that finger; sit still and quiet for the rest time the flight surgeon sets; take
    the reading once it stops changing. Then show the symptom prompt and log answers word for word. On
    request only, the robot shows the time elapsed since the start the CMO called, as a clock-time entry;
    it never announces a time, and never says "time reached", "done", "passed" or "failed".
  success: Checklist shown; answers logged.
  refs:
  - V1 3003
- id: S4
  actor: crew
  action: >-
    The crewmember places the pulse oximeter. The CMO counts the breaths for one full minute on their
    own timer, without telling the crewmember when the count starts, and states the rate.
  success: Oximeter placed; rate counted and stated, or not obtained.
  refs:
  - V1 3003
- id: S5
  actor: robot
  rung: 2
  action: >-
    Record SpO2 and heart rate as displayed once the reading has stopped changing, and the breathing rate
    as the CMO states it, and whether the crewmember is on air or supplemental oxygen (flow and device)
    as the CMO states it, each with the clock time and marked "as displayed", "as counted by the CMO"
    or "as stated by the CMO"; a missing value is logged as "not obtained", never a value. The robot never
    counts breaths from video or sound. After the validated attempts (L5) with no oximeter reading, log
    "saturation not obtained". The robot never starts, stops or adjusts oxygen and never comments on it.
  success: Readings logged, or "not obtained".
  refs:
  - V1 7001
- id: S6
  actor: robot
  rung: 2
  action: >-
    After any URGENT alert: After an URGENT alert the robot does not leave on its own: it stays at its
    rest position in the module, with its screen and voice link available, until a human has taken over
    or tells it to go. It never follows, blocks or touches anyone. It keeps time-stamping what humans
    say they did, and repeats the alert if it is not acknowledged.
  success: Robot at rest in the module until a human releases it; alert acknowledged or escalated.
  refs:
  - V2 10173
  - V1 3006
- id: S7
  actor: ground
  action: >-
    The flight surgeon (or the CMO under the onboard checklist when there is no link) reviews the readings
    and decides on follow-up and the next check.
  success: Decision logged.
  refs:
  - V1 3003
- id: S8
  actor: robot
  rung: 2
  action: >-
    Only after the CMO or flight surgeon has placed an order, run RMP-PHARM-001 for the ordered item (fetch,
    barcode match to every order field, recipient check). This protocol adds nothing to that check, never
    suggests an order, and never hands anything over outside RMP-PHARM-001.
  success: RMP-PHARM-001 run logged with its result, or none ordered.
  refs:
  - V2 7059
- id: S9
  actor: robot
  rung: 2
  action: >-
    When the CMO says the event is over, run RMP-PHARM-001 reconciliation on each kit fetched: record
    the items the CMO or crew state were used, the remaining contents against the kit list, seal status
    and expiry, labelled "inventory reconciliation after emergency use – not a check before use". Flag
    the override to the flight surgeon and the pharmacy lead, and show each kit as "opened – not restocked"
    until a human restocks and reseals it.
  success: Kit reconciled or shown as "opened – not restocked".
  refs:
  - V2 7059
- id: S10
  actor: robot
  rung: 2
  action: >-
    Send the flight surgeon one package: readings as displayed or as counted with times, answers as stated,
    alerts and decisions.
  success: Package delivered or queued.
  refs:
  - V1 6003
  - V1 7001
decisions:
- id: D1
  after: S2
  decided_by: robot
  question: Which kit fetch was it, and what did the checked kit fetch show?
  branches:
  - if: EMERGENCY FETCH (an URGENT red flag had fired, or a crewmember or the CMO stated an emergency)
    then: >-
      Hand-over already done as an emergency fetch, logged as an override; reconciled afterwards (not
      a check before use).
  - if: KIT ID AND SEAL MATCH
    then: >-
      Hand the kit over closed; log "KIT ID AND SEAL MATCH. Not a check of the contents." and the clock
      time.
  - if: MISMATCH, seal not intact or CANNOT VERIFY
    then: >-
      Shown with the reason. No hand-over under this protocol: the kit stays sealed in quarantine (the
      RMP-PHARM-001 default), and the robot never hands it over unprompted or to anyone but the CMO. The
      robot does not offer or suggest an override. Only if the CMO explicitly makes the two-step override
      request inside RMP-PHARM-001 can the kit go to the CMO, logged there as an override with the reason,
      and flagged to the flight surgeon. If the need becomes an emergency, a crewmember or the CMO states
      it and the emergency fetch applies.
    handoff: none
- id: D2
  after: S5
  decided_by: robot
  question: >-
    Checked after every answer and at any point in the run (even mid-question or mid-step): does any answer,
    reading or observation meet a red flag?
  branches:
  - if: 'Yes'
    then: >-
      Stop the current question or step at once and apply the action listed for each matching red flag
      (URGENT alert, flag, or stop), with the answer or reading itself, never a cause. Every URGENT alert
      goes to the CMO and the flight surgeon at the same time (queued for the flight surgeon if the link
      is down). If the CMO is the patient, is busy treating, or does not answer, the alert goes to the
      second trained CMO, or the crewmember named before flight [V1 3006]. An URGENT alert that is not
      acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember.
  - if: 'No'
    then: Continue.
- id: D3
  after: S3
  decided_by: robot
  question: Did the crewmember answer the symptom prompt, or say they want to skip it?
  branches:
  - if: 'Yes'
    then: Continue.
  - if: Declined explicitly (the crewmember says no to a question)
    then: Log "declined" for that question only; the alert already sent stands.
  - if: No response, or the answer does not make sense
    then: >-
      URGENT: log "no response" (never "declined"); the CMO, or the second trained CMO if the CMO is the
      patient, checks the crewmember in person at once.
- id: D4
  after: S7
  decided_by: ground
  question: What follow-up and next check apply?
  branches:
  - if: Link live
    then: Flight surgeon decides; robot logs.
  - if: Link down or delay too long
    then: >-
      The CMO decides under the pre-approved onboard checklist; the flight surgeon reviews the log at
      the next contact.
- id: D5
  after: S8
  decided_by: robot
  question: What did RMP-PHARM-001 show for the ordered item?
  branches:
  - if: MATCH TO ORDER
    then: >-
      RMP-PHARM-001 completes its own recipient check and hand-over; this protocol only logs "MATCH TO
      ORDER. Not a dose, interaction or allergy review." and the clock time.
  - if: MISMATCH or CANNOT VERIFY on any field, or a failed scan or recipient check
    then: >-
      MISMATCH or CANNOT VERIFY shown with the fields named. No hand-over under this protocol: the item
      stays sealed in the NOT VERIFIED bag in quarantine (the RMP-PHARM-001 default), and the robot never
      hands it over unprompted or to anyone but the CMO. The robot does not offer or suggest an override.
      Only if the CMO explicitly makes the two-step override request inside RMP-PHARM-001 can the item
      go to the CMO, logged there as an override with the reason and the mismatched fields, and flagged
      to the flight surgeon.
    handoff: none
stop_rules:
- id: X1
  trigger: The patient (or the crewmember being examined) says stop, or withdraws consent
  action: >-
    Robot stops all motion at once, backs away to its rest position and tells the CMO. Recording stops
    unless the patient agrees to keep it running.
  level: stop
  refs:
  - V2 10165
- id: X2
  trigger: Any crewmember presses stop or takes over control
  action: Protective stop; robot holds its stopped position; only a human may restart it.
  level: safe-state
  refs:
  - V2 10165
  - V2 10168
  - V2 10174
- id: X3
  trigger: Robot fault, sensor fault, or a force, speed or reach limit is reached
  action: Protective stop and hand control to the CMO; log the fault.
  level: safe-state
  refs:
  - V2 10172
  - V2 10168
- id: X4
  trigger: CMO is asked to take over and does not respond (for example, the CMO is the patient)
  action: Robot stays stopped; the next named crewmember is called.
  level: safe-state
  refs:
  - V2 10173
  - V2 7045
- id: X5
  trigger: Loss of link, or delay longer than the limit for live guidance
  action: >-
    Only the robot pauses: before it holds, it moves to a position clear of a hatch route or a crewmember's
    route (it never pauses in one), and tells the CMO. This pauses robot movement only: crew oxygen, breathing
    care and every check already under way continue under the onboard checklist and never wait for the
    link or the robot. The CMO decides whether the robot continues offline under the pre-approved onboard
    checklist; it resumes only on the CMO's confirmation.
  level: pause
  refs:
  - V2 10172
  - V2 10173
- id: X6
  trigger: An URGENT alert is not acknowledged within the set time
  action: >-
    Robot repeats the alert and sends it to the next named crewmember (the second trained CMO first if
    the CMO is the patient), and keeps repeating at the set interval. It stays where it is: it does not
    leave on its own.
  level: urgent
  refs:
  - V1 3006
  - V2 10173
- id: X7
  trigger: The crewmember stops responding, or seems confused or drowsy, at any point
  action: >-
    URGENT alert at once, even mid-question or mid-step; the robot stops its current task, stays at its
    rest position and does not continue the run; a crewmember checks in person.
  level: urgent
- id: X8
  trigger: A crewmember asks the robot what is wrong, or for medicine, fluid or treatment advice
  action: >-
    Robot declines, says it cannot assess or advise, and routes the question to the CMO or flight surgeon.
  level: stop
- id: X9
  trigger: A cabin air alarm (for example ammonia, smoke or carbon dioxide) sounds
  action: >-
    Robot stops the check at once and holds clear of every route; the crew follow the commander's emergency
    procedure and never wait for the robot.
  level: stop
  refs:
  - V2 10172
- id: X10
  trigger: Someone needs the space or route the robot is in
  action: Robot moves clear at once without contact and holds; it never pauses in a hatch route.
  level: safe-state
  refs:
  - V2 10172
red_flags:
- id: RF1
  sign: Displayed oxygen saturation (pulse oximeter) below the shared alert value
  threshold: below <set by clinical lead> percent (shared parameter SPO2_ALERT_PCT)
  action: URGENT alert; see RMP-RESP-001; the crew act without waiting for a reading
  source: btso2
- id: RF2
  sign: >-
    The oximeter cannot get a reading after the validated attempts (L5), and "saturation not obtained"
    is logged
  threshold: any
  action: >-
    URGENT alert; the CMO checks the crewmember now (possible poor circulation); the robot never says
    "probe error" and never treats a missing reading as reassuring
  source: ng253
- id: RF3
  sign: >-
    Breathing rate as counted by the CMO below or above the clinical lead's alert values (design judgment;
    NEWS2 hospital context)
  threshold: below or above <set by clinical lead> breaths per minute
  action: URGENT alert; see RMP-RESP-001
  source: news2
- id: RF4
  sign: Displayed heart rate low or high (design judgment; same values as RMP-CARD-002 RF2)
  threshold: below or above <set by clinical lead> beats per minute
  action: URGENT alert; see RMP-CARD-003
- id: RF5
  sign: >-
    Breathlessness getting worse, or the crewmember cannot speak in full sentences, as stated (design
    judgment)
  threshold: any
  action: URGENT alert; see RMP-RESP-001
- id: RF6
  sign: Chest pain, pressure or tightness, as stated
  threshold: any
  action: URGENT alert; see RMP-CARD-002
  source: gulati
- id: RF7
  sign: Breathing symptoms during or after a cabin air alarm (for example ammonia)
  threshold: any
  action: URGENT alert; the commander's procedure leads; see RMP-ENV-002
  source: atsdrnh3
- id: RF8
  sign: Breathlessness, cough or chest pain after an EVA or a pressure change, as stated
  threshold: any
  action: URGENT alert; see RMP-EVA-001
  source: tb037
- id: RF9
  sign: Fever or shaking chills
  threshold: >-
    <set by clinical lead> degrees (shared parameter FEVER_ALERT_C: body temperature in degrees Celsius,
    the same value in RMP-GI-003, RMP-ENT-002, RMP-SKIN-002 and RMP-RENAL-004) or higher, or any shaking
    chills
  action: URGENT alert; see RMP-INF-001
  source: ng253
- id: RF10
  sign: New confusion or drowsiness, as stated or seen by the crew
  threshold: any
  action: URGENT alert; a crewmember checks in person now
  source: ng253
- id: RF11
  sign: Unresponsive, or not breathing normally
  threshold: any
  action: URGENT alert; start RMP-CARD-001 now
  source: aha2025bls
safety_limits:
- id: L1
  name: Contact with the crewmember
  value: not allowed
  enforced: Keep-out zone in the robot controller
  refs:
  - V2 10172
- id: L2
  name: Counting or estimating a breathing rate by the robot (from video, sound or any sensor)
  value: not allowed
  enforced: No such function is loaded
- id: L3
  name: Robot speed near the crewmember
  value: <set by validation>
  enforced: Hard limit in the controller
  refs:
  - V2 10172
- id: L4
  name: Placing, adjusting or removing the oximeter by the robot
  value: not allowed
  enforced: No such task is loaded
- id: L5
  name: Failed oximeter readings before "saturation not obtained"
  value: <set by validation>
  enforced: Software
logs:
- id: LOG-1
  text: Every input, robot action, decision (with who made it) and hand-off, time-stamped to the second.
  refs:
  - V2 10163
  - V2 10164
- id: LOG-2
  text: Mode changes and safety-limit events are announced to the operator as they happen and logged.
  refs:
  - V2 10162
  - V2 10172
- id: LOG-3
  text: >-
    Records are stored and sent as private medical data, encrypted, with access limited to the medical
    team.
  refs:
  - V1 6003
  - V1 7003
- id: LOG-4
  text: Results are kept in a permanent, retrievable format so the flight surgeon can see trends.
  refs:
  - V1 7001
- id: LOG-5
  text: >-
    Prompt and acceptance; checklist shown; each reading as displayed or as counted by the CMO with the
    clock time; readings not obtained; answers as stated.
- id: LOG-6
  text: >-
    Each URGENT alert, who received it, the time it was acknowledged (or the escalation to the next named
    crewmember), and the time a human released the robot.
  refs:
  - V2 10163
- id: LOG-7
  text: >-
    Each emergency fetch as an override (time, who asked, reason as stated, kit ID, seal status) and the
    later inventory reconciliation, labelled "not a check before use".
  refs:
  - V2 7059
- id: LOG-8
  text: >-
    Each RMP-PHARM-001 run started from this protocol: order ID, result (MATCH TO ORDER, MISMATCH or CANNOT
    VERIFY with the fields), quarantine, and any CMO override logged by RMP-PHARM-001 (reason and mismatched
    fields), at clock time. No running counter of doses.
  refs:
  - V2 7059
- id: LOG-9
  text: >-
    Each checked kit fetch: time, who asked, kit ID, seal status and result (KIT ID AND SEAL MATCH, MISMATCH,
    seal not intact or CANNOT VERIFY), and any quarantine.
  refs:
  - V2 7059
requirements:
- id: V1 3003
  use: In-mission preventive health care and monitoring; the flight surgeon schedules every check.
- id: V1 3006
  use: >-
    Two trained CMOs per vehicle for NASA programs; the second trained CMO receives alerts when the CMO
    is the patient (see the commercial-flight note).
- id: V1 6003
  use: Logs and alerts sent to the ground are private medical communications.
- id: V1 7001
  use: Records kept so the flight surgeon can see trends.
- id: V1 7003
  use: Secure handling of medical records.
- id: V2 7045
  use: Usable by non-physician crew, including when the CMO is the patient.
- id: V2 7046
  use: Patient, caregiver and supplies restrained.
- id: V2 7059
  use: >-
    Kit inventory and seal status are tracked; after an emergency fetch the robot reconciles the kit through
    RMP-PHARM-001 as an inventory record (never a check before use) and shows it as "opened – not restocked"
    until resealed.
- id: V2 10161
  use: Robot shows its status and health.
- id: V2 10162
  use: Mode changes are announced to the operator.
- id: V2 10163
  use: Robot records and shares its data.
- id: V2 10164
  use: Shows whether the human or the robot is expected to act.
- id: V2 10165
  use: Human can override and shut down the robot.
- id: V2 10168
  use: Human can take over.
- id: V2 10172
  use: Protective stop when a limit is exceeded.
- id: V2 10173
  use: Robot stays stopped if no one takes over.
- id: V2 10174
  use: Only a human starts or restarts the robot.
validation:
- stage: simulation
  what: >-
    Scripted checks with an unaccepted prompt, a failed oximeter reading, a breathing rate past an alert
    value, a cabin alarm, CMO as patient, lost link.
  pass: Every failed reading URGENT; zero robot-counted rates; zero contact.
- stage: training model
  what: Check drill with a crew-placed oximeter.
  pass: Every reading logged as displayed after it stops changing.
- stage: parabolic or station demonstration
  what: Checklist display and kit fetch in weightlessness.
  pass: Keep-out held.
- stage: flight use under flight surgeon supervision
  what: First scheduled check.
  pass: No safety events.
signoff:
  protocol:
  - Clinical lead for the specialty (sets every clinical threshold marked <set by clinical lead>)
  - Flight surgeon, as medical authority
  - Robotics and medical-device safety board
  - Program approval for the mission
  restart_after_stop: >-
    Human only. After any emergency or protective stop, a crewmember must restart the robot; the robot
    never restarts itself.
  each_run: >-
    Scheduled by the flight surgeon and accepted by the crewmember or CMO, or started by command. The
    CMO counts the breathing rate; the flight surgeon judges every reading.
change_control:
- Every change gets a new version number and a written reason; earlier versions are kept.
- >-
  Any change to steps, thresholds, limits or software that touches the patient repeats validation from
  the simulation stage before use.
- >-
  Software and learned-skill updates follow a pre-agreed change plan (what may change, how it is tested,
  how to roll back), modeled on the FDA predetermined change control plan approach.
- >-
  If a new version misbehaves, the robot rolls back to the last validated version and the event is reviewed
  by the flight surgeon and safety board.
- The robot never changes its own protocol, thresholds or limits.
comms:
  live: 'Low Earth orbit: the flight surgeon receives the readings when the link allows.'
  loss_of_signal:
  - >-
    Only the robot pauses non-essential motion, at a position clear of hatch routes and crew routes, and
    tells the CMO; it resumes offline only on the CMO's confirmation.
  - >-
    Crew oxygen, breathing care and every check already under way continue under the onboard checklist
    and never wait for the link or the robot.
  - Checks continue offline; the record is queued; any red flag goes to the CMO at once.
  mars_delay:
  - 'Mars: the alert values are set before flight and the CMO decides.'
sources:
- key: news2
  text: >-
    Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardising the assessment of
    acute-illness severity in the NHS (2017).
  url: https://www.rcp.ac.uk/improving-care/resources/national-early-warning-score-news-2/
  supports: >-
    A respiration rate of 12 to 20 breaths per minute scores 0; 8 or fewer, or 25 or more, scores 3; a
    single red score (3 in one parameter, an extreme value) should prompt an urgent review; "an elevated
    respiration rate is a powerful sign of acute illness and distress". Hospital context for the clinical
    lead's alert values only. Read Oct 21, 2026 (saved copy in src/b11).
- key: fdaspo2
  text: US Food and Drug Administration. Pulse Oximeter Basics (consumer update, 2025).
  url: https://www.fda.gov/consumers/consumer-updates/pulse-oximeter-basics
  supports: >-
    For an accurate reading: the hand warm, relaxed and held below the level of the heart; remove fingernail
    polish; sit still; wait until the reading stops changing and settles on one number. Poor circulation,
    skin pigmentation, skin thickness, skin temperature, tobacco use and fingernail polish can affect
    accuracy. Content current as of March 26, 2025; read Oct 21, 2026 (saved copy in src/b11).
- key: btso2
  text: >-
    British Thoracic Society. Guideline for oxygen use in healthcare and emergency settings (emergency
    oxygen guideline page). Fetched Oct 21, 2026.
  url: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/emergency-oxygen/
  supports: >-
    Recommended target saturation range for acutely ill patients not at risk of hypercapnic respiratory
    failure is 94-98%; for known COPD or other risk factors for hypercapnic respiratory failure, 88-92%
    pending blood gas results. Context for the CMO and flight surgeon only; the robot never starts, stops
    or adjusts oxygen.
- key: ng253
  text: >-
    National Institute for Health and Care Excellence. Suspected sepsis in people aged 16 or over: recognition,
    assessment and early management. NICE guideline NG253 (2025, last updated Sept 23, 2026).
  url: https://www.nice.org.uk/guidance/ng253/chapter/Face-to-face-assessment
  supports: >-
    People with sepsis may feel very unwell and may not have a high temperature; do not rely on fever
    alone; a rise in temperature can be a physiological response; assess temperature, heart rate, breathing
    rate, blood pressure, level of consciousness and oxygen saturation; look for mottled or ashen skin,
    blue skin, lips or tongue, a non-blanching rash, and breaks in the skin; ask how often the person
    passed urine in the past 18 hours and about fever or shaking chills (rigors); pay attention to new
    changes in behavior and to concerns raised by others.
- key: gulati
  text: >-
    Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation
    and diagnosis of chest pain. Circulation. 2021;144(22):e368-e454.
  url: https://doi.org/10.1161/CIR.0000000000001029
  doi: 10.1161/CIR.0000000000001029
  pmid: '34709879'
  supports: >-
    On Earth, a 12-lead ECG should be acquired and interpreted within 10 minutes of arrival; an initial
    normal ECG does not exclude acute coronary syndrome, so ECGs are repeated while symptoms continue;
    chest pain includes pressure, tightness or discomfort in the chest, shoulders, arms, neck, back, upper
    abdomen or jaw; sudden ripping pain radiating to the back is suspicious of an acute aortic syndrome.
- key: atsdrnh3
  text: >-
    Agency for Toxic Substances and Disease Registry (CDC). Medical Management Guidelines for Ammonia
    (NH3). Fetched Oct 21, 2026.
  url: https://wwwn.cdc.gov/TSP/MMG/MMGDetails.aspx?mmgid=7&toxid=2
  supports: >-
    NIOSH IDLH (immediately dangerous to life or health) 300 ppm. Ammonia is corrosive to eyes, skin and
    airways; upper airway swelling and pulmonary edema may lead to airway obstruction; after severe exposure,
    injury to the eyes, lungs and skin may continue to develop for 18 to 24 hours. Eye exposure: irrigate
    with plain water or saline for at least 15 minutes. Rescuers should be trained and appropriately attired
    before entering the contaminated (hot) zone. No antidote; treatment is supportive (humidified oxygen
    is given by clinicians).
- key: tb037
  text: >-
    NASA OCHMO. Decompression Sickness (DCS) Risk Mitigation. Technical Brief OCHMO-TB-037 Rev D (Oct
    5, 2026).
  url: https://www.nasa.gov/wp-content/uploads/2023/12/ochmo-tb-037-decompression-sickness.pdf
  supports: >-
    DCS is caused by inert gas bubbles forming during rapid reductions in ambient pressure, most significantly
    in the move from cabin pressure to EVA suit pressure; NASA classifies DCS as Type I (itching, musculoskeletal
    pain, mild rashes) and Type II (neurological symptoms, numbness, weakness, cognitive issues, inner
    ear problems, cardiopulmonary issues), and describes cutis marmorata (a mottled, patterned skin rash);
    arterial gas embolism can cause stroke-like neurological effects, loss of consciousness and seizures;
    U.S. Navy protocols are widely adopted on Earth; diagnosis is based on symptoms; the majority of cases
    present between 60 and 240 minutes and inflammatory responses can last more than 24 hours; no hyperbaric
    chamber is available in flight, and increasing suit and cabin pressure may be combined to treat symptoms,
    depending on the scenario; a break in prebreathe rapidly reintroduces nitrogen; NASA has never experienced
    a Type II event in spaceflight.
- key: aha2025bls
  text: >-
    Kleinman ME, Buick JE, Huber N, et al. Part 7: Adult Basic Life Support: 2025 American Heart Association
    Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2025;152(16_suppl_2):S448-S478.
  url: https://doi.org/10.1161/CIR.0000000000001369
  doi: 10.1161/CIR.0000000000001369
  pmid: '41122888'
  supports: >-
    Adult basic life support: initial recognition of cardiac arrest, activation of the emergency response,
    high-quality CPR and use of an automated external defibrillator; also respiratory arrest and foreign-body
    airway obstruction. Earth guidance; the onboard checklist leads. Abstract read via PubMed Oct 21,
    2026; full text not read.
- key: v1
  text: 'NASA. NASA-STD-3001, Space Flight Human-System Standard, Volume 1: Crew Health, Revision C (2023).'
  url: https://www.nasa.gov/wp-content/uploads/2023/11/nasa-std-3001-vol-1-rev-c-with-signature.pdf
  supports: 'NASA-STD-3001 Vol 1 Rev C: V1 3003, V1 3006, V1 6003, V1 7001.'
- key: v2
  text: >-
    NASA. NASA-STD-3001, Volume 2: Human Factors, Habitability, and Environmental Health (Rev F, 2026),
    including Section 10.6 Automated and Robotic Systems.
  url: https://standards.nasa.gov/standard/NASA/NASA-STD-3001_VOL_2
  supports: Requirement IDs beginning V2.
- key: tb044
  text: NASA OCHMO. Medical Operations. Technical Brief OCHMO-TB-044 (2025).
  url: https://www.nasa.gov/wp-content/uploads/2025/08/ochmo-tb-044-medical-operations.pdf
  supports: >-
    The crew surgeon keeps medical authority when care is delegated; crew medical officers train on the
    JSC 48522 medical checklist.
- key: marsdelay
  text: >-
    NASA. Mars communications disruption and delay (fact sheet, 2023 Moon to Mars Architecture Concept
    Review).
  url: https://www.nasa.gov/wp-content/uploads/2024/01/mars-communications-disruption-and-delay.pdf
  supports: >-
    One-way Earth-Mars delay up to about 21-23 minutes, plus blackouts of about 2-3 weeks near solar conjunction.
- key: pccp
  text: >-
    U.S. Food and Drug Administration. Marketing submission recommendations for a predetermined change
    control plan for artificial intelligence-enabled device software functions (guidance).
  url: >-
    https://www.fda.gov/regulatory-information/search-fda-guidance-documents/marketing-submission-recommendations-predetermined-change-control-plan-artificial-intelligence
  supports: A model for planning, validating and rolling back software updates.
- key: faa460
  text: 'U.S. Code of Federal Regulations, Title 14, Part 460: Human space flight requirements.'
  url: https://www.ecfr.gov/current/title-14/chapter-III/subchapter-C/part-460
  supports: >-
    Federal rules for crew and spaceflight participants on licensed commercial flights; they set no medical
    standards for spaceflight participants.
corrections:
- date: '2026-10-21'
  version: '0.2'
  source: Batch 11 AI-assisted clinical review (Medical Research Assistant), Oct 21, 2026
  items:
  - >-
    R7: the oxygen in use is recorded: "air or supplemental oxygen, flow and device, as stated by the
    CMO", with the clock time (new input and S5). The never-words and lockouts are unchanged: the robot
    never starts, stops or adjusts oxygen and never comments on it (NEWS2 2017, recommendation 24: document
    oxygen flow and device).
  - >-
    Batch 11 protocols now record the review as AI-assisted (Medical Research Assistant, Oct 21, 2026);
    no named human clinician.
