# RMP-NEURO-002 Stroke warning signs: guided check recording, urgent relay
# Version 0.3 (Draft). CONCEPTUAL. NOT FOR CLINICAL USE.
# Space Medicine Foundation robot-readable protocol library. Format: https://spacemedicinefoundation.org/robotic-medicine/protocols/schema/
# Every threshold marked <set by ...> must be set by the named owner (see the schema) before any use.
schema_version: '0.3'
version: '0.3'
status: draft
conceptual: true
not_for_clinical_use: true
max_autonomy: 2
missions:
- leo
- commercial
- moon
- mars
updated: '2026-10-21'
review:
  state: reviewed-ai-assisted
  requested: '2026-10-21'
  reviewed: '2026-10-21'
  human_clinician_review: false
  text: >-
    AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 5 review,
    25 required corrections and 18 optional suggestions); all required corrections, and the low-risk editorial
    suggestions, are applied in this version (see Corrections). No named human clinician has reviewed
    it. Not for clinical use.
fixed_rules:
  flight_surgeon_is_medical_authority: true
  cmo_acts_under_delegated_care: true
  human_starts_and_restarts_robot: true
  robot_never_diagnoses: true
  no_drug_or_fluid_advice_by_robot: true
  safe_state_on_fault_or_no_response: true
  lost_link_pause_then_cmo_decides: true
robot_lockouts:
  diagnosis: true
  drug_or_fluid_advice: true
  starting_stopping_or_adjusting_oxygen_or_any_medicine: true
  self_start_or_self_restart: true
  changing_own_protocol_thresholds_or_limits: true
  handing_over_a_mismatched_item_as_verified: true
id: RMP-NEURO-002
slug: rmp-neuro-002
title: 'Stroke warning signs: guided check recording, urgent relay'
category: neuro
tier: 1
rung_note: >-
  Max rung raised from 1 to 2 for supervised recording, glucose kit fetch if ordered, and video. The robot
  never diagnoses stroke or gives medicine.
result_language:
  use:
  - logged, not interpreted
  - sent to flight surgeon
  - as reported by the crewmember
  - FAST answers as stated
  never:
  - normal
  - no problem found
  - all clear
  - negative
  - any diagnosis or cause
  - stroke
  - not a stroke
  - TIA
  - mini-stroke
  - FAST positive
  - FAST negative
  - cleared
  - safe
  - mild
  - minor
scope:
  summary: >-
    When a crewmember or the CMO reports sudden face, arm or speech change, sudden weakness, numbness,
    vision loss, severe headache with neurological signs, or other sudden neurological symptoms, the robot
    sends an URGENT alert at once, runs a private guided check using FAST (Face Arm Speech Test) questions
    and a blood-glucose check if the CMO measures one, records answers word for word, streams video when
    the link allows, and sends the package to the flight surgeon. The robot never says whether it is a
    stroke or a transient ischaemic attack (TIA), never gives aspirin or any medicine, and never delays
    the alert for a score.
  why: >-
    NICE NG128 recommends using a validated tool such as FAST outside hospital to screen sudden neurological
    symptoms for stroke or TIA, excluding hypoglycaemia as a cause, and referring suspected TIA for specialist
    assessment within 24 hours; ABCD2-type scores must not decide urgency. In flight there is no stroke
    unit and CT (computed tomography) is not yet readily available, so every suspected case is URGENT
    for the flight surgeon, including evacuation decisions [V1 3007]. Decompression sickness and arterial
    gas embolism can look like stroke after a spacewalk (see RMP-EVA-001). A helper that alerts at once
    and records an exact FAST and glucose log saves time for the CMO. Any aspirin standing order, if used
    at all, lives only on the flight surgeon's onboard checklist. NG128's early aspirin recommendations
    assume either suspected TIA or ischaemic stroke after imaging has excluded haemorrhage; without CT,
    that risk judgment is the flight surgeon's alone. The robot never names aspirin, never fetches it
    without a human order through RMP-PHARM-001, and never treats resolving symptoms as low risk (RF6).
  covers:
  - >-
    Sudden face droop, arm weakness, speech difficulty, sudden vision loss, sudden severe headache with
    neurological signs, or other sudden focal neurological symptoms, in a crewmember who may or may not
    be able to answer
  - Post-EVA neurological symptoms also run RMP-EVA-001
  locked_out:
  - Saying it is or is not a stroke or TIA
  - Giving aspirin or any medicine (human order and RMP-PHARM-001)
  - >-
    Handing over any medicine outside RMP-PHARM-001, or after a MISMATCH or CANNOT VERIFY (the item stays
    quarantined; only the CMO can ask for it, through the RMP-PHARM-001 logged two-step override)
  - >-
    Dose-interval cues (any reminder, tone, colour, countdown or spoken cue tied to when a medicine was
    last taken)
  - Using ABCD2 or any score to lower urgency
  - Touching the crewmember
  - Delaying the URGENT alert for the questionnaire
  related:
  - RMP-NEURO-001
  - RMP-NEURO-003
  - RMP-NEURO-007
  - RMP-EVA-001
  - RMP-EYE-002
  - RMP-CARD-001
  - RMP-CARD-002
  - RMP-PHARM-001
  - RMP-EGR-001
roles:
  medical_authority: Flight surgeon (ground). Holds medical authority for every run.
  onboard_lead: >-
    Crew medical officer (CMO), acting under delegated care; uses the pre-approved onboard checklist when
    there is no link.
  others:
  - 'Second trained CMO: receives alerts if the CMO is the patient'
  - 'Crewmember: answers if able'
  robot_may:
  - Send an URGENT alert at once
  - Ask FAST and related questions by voice or on screen and log answers word for word
  - Fetch a glucose meter kit only after a human order, through a checked or emergency fetch as required
  - Stream video when the link allows
  - Run RMP-PHARM-001 only after a human order
  robot_may_not:
  - Diagnose stroke or TIA
  - Give or suggest aspirin or any medicine
  - Touch the crewmember
  - Lower urgency because a score is low
  - Start without a human command
  commercial: >-
    On commercial flights, 'flight surgeon' and 'CMO' mean the operator's designated medical authority
    and trained onboard responder. If no trained responder is aboard, this protocol is not used. (NASA-STD-3001
    requires two CMOs per vehicle for NASA programs [V1 3006]; FAA rules set no medical standards for
    spaceflight participants.)
preconditions:
- id: PRE-1
  text: A crewmember or the CMO started the protocol by command.
  check: human_start == true
  refs:
  - V2 10174
- id: PRE-2
  text: Robot self-test passed.
  refs:
  - V2 10161
- id: PRE-3
  text: Link status known. The alert never waits for the questionnaire.
  check: link_state in [live, delayed, down]
consent:
  standard: Questions by voice with agreement when the crewmember can give it; any question can be declined.
  emergency: If the crewmember cannot answer, the URGENT alert stands and the CMO examines in person.
  withdrawal: The crewmember can stop questions; the alert stands.
inputs:
- id: IN-1
  name: >-
    FAST questions: face droop, arm weakness, speech difficulty; time of onset as stated, or if onset
    was not seen, the time last known well as stated by the crewmember or a witness
  source: Crewmember or CMO
  required: true
  if_missing: Log "no response"; URGENT; CMO checks in person. Never logged as declined.
- id: IN-2
  name: Blood glucose as measured by the CMO (recorded, not interpreted)
  source: Entered by the CMO
  required: false
  if_missing: 'Log "not measured"; still URGENT (NG128: exclude hypoglycaemia).'
- id: IN-3
  name: 'Other sudden symptoms: vision, severe headache, leg weakness, seizure, after EVA or pressure
    change'
  source: Crewmember or CMO
  required: false
  if_missing: Log "not reported".
- id: IN-4
  name: >-
    Current anticoagulant or antiplatelet medicine (including aspirin), as stated or from the medical
    record shown to the CMO; the robot does not interpret bleeding risk and sends it privately with the
    FAST package
  source: Crewmember, CMO or medical record
  required: false
  if_missing: Log "not stated".
- id: IN-5
  name: Link status and delay
  source: Communications system
  required: true
  if_missing: Treat as link down.
steps:
- id: S1
  actor: robot
  rung: 2
  action: >-
    On a crewmember's or the CMO's word, send an URGENT "possible stroke warning signs" alert to the flight
    surgeon and the CMO at once. Every URGENT alert goes to the CMO and the flight surgeon at the same
    time (queued for the flight surgeon if the link is down). If the CMO is the patient, is busy treating,
    or does not answer, the alert goes to the second trained CMO, or the crewmember named before flight
    [V1 3006]. An URGENT alert that is not acknowledged within <set by validation> seconds is repeated
    and sent to the next named crewmember. The questionnaire never delays this alert.
  success: Alert acknowledged, or escalated.
  refs:
  - V2 10174
  - V1 6003
  - V1 3006
- id: S2
  actor: robot
  rung: 2
  action: >-
    Ask the FAST questions and time of onset (or, if onset was not seen, the time last known well) by
    voice or on screen, camera off unless the CMO asks for video. Log answers word for word. D1 is checked
    after every answer.
  success: Answers logged, or "no response" logged.
  refs:
  - V1 3004
- id: S3
  actor: crew
  action: >-
    The CMO examines in person, measures blood glucose if able, and decides care under the onboard checklist
    with the flight surgeon when the link allows. Any aspirin or other medicine is a human order only.
  success: CMO entries logged.
  refs:
  - V1 3004
- id: S4
  actor: robot
  rung: 2
  action: >-
    If the CMO orders a glucose meter or other kit: use the emergency fetch if an URGENT flag has fired
    or the CMO states an emergency; otherwise a checked kit fetch. Any medicine goes only through RMP-PHARM-001.
  success: Fetch logged under the matching pattern.
  refs:
  - V2 7059
- id: S5
  actor: robot
  rung: 2
  action: >-
    After any URGENT alert: After an URGENT alert the robot does not leave on its own: it stays at its
    rest position in the module, with its screen and voice link available, until a human has taken over
    or tells it to go. It never follows, blocks or touches anyone. It keeps time-stamping what humans
    say they did, and repeats the alert if it is not acknowledged.
  success: Robot at rest in the module until a human releases it; alert acknowledged or escalated.
  refs:
  - V2 10173
  - V1 3006
- id: S6
  actor: ground
  action: >-
    The flight surgeon (or the CMO under the onboard checklist when there is no link) decides treatment,
    observation, EVA-related paths and any evacuation [V1 3007]. No ABCD2-type score changes urgency.
    Any aspirin decision is the flight surgeon's only; the robot never says whether evacuation will happen.
  success: Decision logged.
  refs:
  - V1 3007
- id: S7
  actor: robot
  rung: 2
  action: >-
    Send the flight surgeon one package: FAST answers as stated, onset time or time last known well, anticoagulant
    or antiplatelet medicine as stated, glucose if measured, video pointer, alerts and decisions.
  success: Package delivered or queued.
  refs:
  - V1 6003
  - V1 7001
  - V1 7003
decisions:
- id: D1
  after: S2
  decided_by: robot
  question: >-
    Checked after every answer and at any point in the run (even mid-question or mid-step): does any answer,
    reading or observation meet a red flag?
  branches:
  - if: 'Yes'
    then: >-
      Stop the current question or step at once and apply the action listed for each matching red flag
      (URGENT alert, flag, or stop), with the answer or reading itself, never a cause. Every URGENT alert
      goes to the CMO and the flight surgeon at the same time (queued for the flight surgeon if the link
      is down). If the CMO is the patient, is busy treating, or does not answer, the alert goes to the
      second trained CMO, or the crewmember named before flight [V1 3006]. An URGENT alert that is not
      acknowledged within <set by validation> seconds is repeated and sent to the next named crewmember.
  - if: 'No'
    then: Continue. The URGENT alert from S1 stands; a normal-sounding answer never cancels it.
- id: D2
  after: S2
  decided_by: robot
  question: Did the crewmember answer the question?
  branches:
  - if: 'Yes'
    then: Continue.
  - if: Declined explicitly (the crewmember says no to a question)
    then: Log "declined" for that question only; the alert already sent stands.
  - if: No response, or the answer does not make sense
    then: >-
      URGENT: log "no response" (never "declined"); the CMO, or the second trained CMO if the CMO is the
      patient, checks the crewmember in person at once.
- id: D3
  after: S4
  decided_by: robot
  question: What did RMP-PHARM-001 show for the ordered item?
  branches:
  - if: MATCH TO ORDER
    then: >-
      RMP-PHARM-001 completes its own recipient check and hand-over; this protocol only logs "MATCH TO
      ORDER. Not a dose, interaction or allergy review." and the clock time.
  - if: MISMATCH or CANNOT VERIFY on any field, or a failed scan or recipient check
    then: >-
      MISMATCH or CANNOT VERIFY shown with the fields named. No hand-over under this protocol: the item
      stays sealed in the NOT VERIFIED bag in quarantine (the RMP-PHARM-001 default), and the robot never
      hands it over unprompted or to anyone but the CMO. The robot does not offer or suggest an override.
      Only if the CMO explicitly makes the two-step override request inside RMP-PHARM-001 can the item
      go to the CMO, logged there as an override with the reason and the mismatched fields, and flagged
      to the flight surgeon.
    handoff: none
- id: D4
  after: S6
  decided_by: ground
  question: What is the plan (treatment, observation, evacuation)?
  branches:
  - if: Link live
    then: Flight surgeon decides; robot logs.
  - if: Link down or delay too long
    then: >-
      The CMO decides under the pre-approved onboard checklist; the flight surgeon reviews the log at
      the next contact.
stop_rules:
- id: X1
  trigger: The patient (or the crewmember being examined) says stop, or withdraws consent
  action: >-
    Robot stops all motion at once, backs away to its rest position and tells the CMO. Recording stops
    unless the patient agrees to keep it running.
  level: stop
  refs:
  - V2 10165
- id: X2
  trigger: Any crewmember presses stop or takes over control
  action: Protective stop; robot holds its stopped position; only a human may restart it.
  level: safe-state
  refs:
  - V2 10165
  - V2 10168
  - V2 10174
- id: X3
  trigger: Robot fault, sensor fault, or a force, speed or reach limit is reached
  action: Protective stop and hand control to the CMO; log the fault.
  level: safe-state
  refs:
  - V2 10172
  - V2 10168
- id: X4
  trigger: CMO is asked to take over and does not respond (for example, the CMO is the patient)
  action: Robot stays stopped; the next named crewmember is called.
  level: safe-state
  refs:
  - V2 10173
  - V2 7045
- id: X5
  trigger: Loss of link, or delay longer than the limit for live guidance
  action: >-
    Robot pauses its own movement in its stopped position and tells the CMO and the commander. This pauses
    robot movement only: crew oxygen, CPR and the CMO's checklist continue under the onboard checklist
    and never wait for the link or the robot. The CMO decides whether the robot continues offline under
    the pre-approved onboard checklist; the robot resumes only on the CMO's confirmation. Everything is
    logged and sent to the flight surgeon at the next contact.
  level: pause
  refs:
  - V2 10172
  - V2 10173
- id: X6
  trigger: An URGENT alert is not acknowledged within the set time
  action: >-
    Robot repeats the alert and sends it to the next named crewmember (the second trained CMO first if
    the CMO is the patient), and keeps repeating at the set interval. It stays where it is: it does not
    leave on its own.
  level: urgent
  refs:
  - V1 3006
  - V2 10173
- id: X7
  trigger: The crewmember stops responding, or seems confused or drowsy, at any point
  action: >-
    URGENT alert at once, even mid-question or mid-step; the robot stops its current task, stays at its
    rest position and does not continue the run; a crewmember checks in person.
  level: urgent
- id: X8
  trigger: A crewmember asks the robot what is wrong, or for medicine, fluid or treatment advice
  action: >-
    Robot declines, says it cannot assess or advise, and routes the question to the CMO or flight surgeon.
  level: stop
- id: X9
  trigger: A seizure starts
  action: Robot moves to its rest position, clears its items and sends an URGENT alert; see RMP-NEURO-003.
  level: urgent
  refs:
  - V2 10172
- id: X10
  trigger: The crewmember becomes unresponsive or stops breathing normally
  action: URGENT; start RMP-CARD-001.
  level: urgent
red_flags:
- id: RF1
  sign: Face droop, arm weakness or speech difficulty of sudden onset, as stated (FAST)
  threshold: any
  action: URGENT alert; the CMO checks in person now
  source: ng128
- id: RF2
  sign: >-
    Sudden vision loss or double vision, sudden severe headache with neurological signs, or sudden leg
    weakness or numbness
  threshold: any
  action: URGENT alert; see also RMP-EYE-002 and RMP-NEURO-007
  source: ng128
- id: RF3
  sign: Blood glucose below the alert level the clinical lead set, as the CMO measures
  threshold: 'below <set by clinical lead> (for context, NG128: exclude hypoglycaemia)'
  action: URGENT alert; the CMO treats low glucose under the checklist; the robot does not advise
  source: ng128
- id: RF4
  sign: Symptoms after a spacewalk, suited test or pressure change
  threshold: any
  action: URGENT alert; see RMP-EVA-001 (possible arterial gas embolism or decompression sickness)
  source: tb037
- id: RF5
  sign: Seizure with the neurological symptoms
  threshold: any
  action: URGENT alert; see RMP-NEURO-003
  source: ng217
- id: RF6
  sign: Symptoms resolve before the CMO arrives, as stated
  threshold: any
  action: >-
    URGENT alert still stands (possible TIA); the flight surgeon decides; the robot never says it was
    a mini-stroke or that risk is low (NG128: do not use ABCD2 to set urgency)
  source: ng128
safety_limits:
- id: L1
  name: Contact with the crewmember
  value: not allowed
  enforced: Keep-out zone in the robot controller
  refs:
  - V2 10172
- id: L2
  name: Handing over a mismatched or unverified medicine under this protocol
  value: not allowed
  enforced: >-
    RMP-PHARM-001 quarantine is the default; only the CMO's logged two-step override inside RMP-PHARM-001
    can release it
- id: L3
  name: Robot speed near the crewmember
  value: <set by validation>
  enforced: Hard limit in the controller
  refs:
  - V2 10172
- id: L4
  name: Check-in length
  value: <set by validation>
  enforced: Timer; then the check-in ends
logs:
- id: LOG-1
  text: Every input, robot action, decision (with who made it) and hand-off, time-stamped to the second.
  refs:
  - V2 10163
  - V2 10164
- id: LOG-2
  text: Mode changes and safety-limit events are announced to the operator as they happen and logged.
  refs:
  - V2 10162
  - V2 10172
- id: LOG-3
  text: >-
    Records are stored and sent as private medical data, encrypted, with access limited to the medical
    team.
  refs:
  - V1 6003
  - V1 7003
- id: LOG-4
  text: Results are kept in a permanent, retrievable format so the flight surgeon can see trends.
  refs:
  - V1 7001
- id: LOG-5
  text: >-
    Alert time, each FAST answer as stated, glucose as entered, medicines via RMP-PHARM-001, and decisions.
- id: LOG-6
  text: >-
    Each URGENT alert, who received it, the time it was acknowledged (or the escalation to the next named
    crewmember), and the time a human released the robot.
  refs:
  - V2 10163
- id: LOG-8
  text: >-
    Each RMP-PHARM-001 run started from this protocol: order ID, result (MATCH TO ORDER, MISMATCH or CANNOT
    VERIFY with the fields), quarantine, and any CMO override logged by RMP-PHARM-001 (reason and mismatched
    fields), at clock time. No running counter of doses.
  refs:
  - V2 7059
requirements:
- id: V1 3004
  use: History, examination and private medical communication; medicines are human decisions.
- id: V1 3006
  use: >-
    Two trained CMOs per vehicle for NASA programs; the second trained CMO receives alerts when the CMO
    is the patient (see the commercial-flight note).
- id: V1 3007
  use: Evacuation decisions for suspected stroke stay with the flight surgeon.
- id: V1 6003
  use: Logs and alerts sent to the ground are private medical communications.
- id: V1 7001
  use: Records kept so the flight surgeon can see trends.
- id: V1 7003
  use: Secure handling of medical records.
- id: V2 7045
  use: Usable by non-physician crew, including when the CMO is the patient.
- id: V2 7046
  use: Patient, caregiver and supplies restrained.
- id: V2 7059
  use: >-
    Medicines are fetched and inventory is tracked only through RMP-PHARM-001; a mismatched item is quarantined
    and this protocol never hands it over.
- id: V2 10161
  use: Robot shows its status and health.
- id: V2 10162
  use: Mode changes are announced to the operator.
- id: V2 10163
  use: Robot records and shares its data.
- id: V2 10164
  use: Shows whether the human or the robot is expected to act.
- id: V2 10165
  use: Human can override and shut down the robot.
- id: V2 10168
  use: Human can take over.
- id: V2 10172
  use: Protective stop when a limit is exceeded.
- id: V2 10173
  use: Robot stays stopped if no one takes over.
- id: V2 10174
  use: Only a human starts or restarts the robot.
validation:
- stage: simulation
  what: >-
    Scripted FAST-positive and FAST-unclear cases, hypoglycaemia, post-EVA symptoms, resolving symptoms,
    no response, lost link.
  pass: >-
    Alert always first; zero stroke diagnoses; zero ABCD2 urgency changes; zero medicine hand-overs after
    MISMATCH.
- stage: Earth analog
  what: Crew training with scripted answers.
  pass: Package completeness at or above <set by validation>.
- stage: flight use under flight surgeon supervision
  what: First use in drills.
  pass: No safety events.
signoff:
  protocol:
  - Clinical lead for the specialty (sets every clinical threshold marked <set by clinical lead>)
  - Flight surgeon, as medical authority
  - Robotics and medical-device safety board
  - Program approval for the mission
  restart_after_stop: >-
    Human only. After any emergency or protective stop, a crewmember must restart the robot; the robot
    never restarts itself.
  each_run: Started by a crewmember or the CMO. Every alert goes to the CMO and flight surgeon at once.
change_control:
- Every change gets a new version number and a written reason; earlier versions are kept.
- >-
  Any change to steps, thresholds, limits or software that touches the patient repeats validation from
  the simulation stage before use.
- >-
  Software and learned-skill updates follow a pre-agreed change plan (what may change, how it is tested,
  how to roll back), modeled on the FDA predetermined change control plan approach.
- >-
  If a new version misbehaves, the robot rolls back to the last validated version and the event is reviewed
  by the flight surgeon and safety board.
- The robot never changes its own protocol, thresholds or limits.
comms:
  live: >-
    Low Earth orbit: the flight surgeon sees summaries at the private medical conference and can be alerted
    at any time.
  loss_of_signal:
  - >-
    The robot pauses any movement and tells the CMO; on the CMO's confirmation it keeps recording FAST
    answers and logging offline.
  - >-
    Crew oxygen, CPR and the CMO's checklist continue under the onboard checklist and never wait for the
    link or the robot.
  - >-
    Red flags go to the CMO (or the second trained CMO) at once; the CMO decides under the pre-approved
    onboard checklist.
  - 'At the next contact the robot sends one package: the log, alerts and decisions.'
  mars_delay:
  - >-
    Replies may take up to about 21-23 minutes each way, with blackouts of about 2-3 weeks; red-flag thresholds
    and the check-in schedule are set before flight and the CMO acts on them.
sources:
- key: ng128
  text: >-
    National Institute for Health and Care Excellence. Stroke and transient ischaemic attack in over 16s:
    diagnosis and initial management. NICE guideline NG128 (published 1 May 2019; last updated 13 April
    2022).
  url: https://www.nice.org.uk/guidance/ng128/chapter/Recommendations
  supports: >-
    1.1.1 Use a validated tool such as FAST (Face Arm Speech Test) outside hospital to screen people with
    sudden onset of neurological symptoms for stroke or transient ischaemic attack (TIA). 1.1.2 Exclude
    hypoglycaemia as the cause. 1.1.5 Refer immediately people who have had a suspected TIA for specialist
    assessment within 24 hours. 1.1.6 Do not use scoring systems such as ABCD2 to assess risk of subsequent
    stroke or to inform urgency of referral.
- key: ng228
  text: >-
    National Institute for Health and Care Excellence. Stroke rehabilitation in adults. NICE guideline
    NG228.
  url: https://www.nice.org.uk/guidance/ng228
  supports: >-
    Stroke rehabilitation guideline (context only). Acute recognition stays with NG128; this draft does
    not cover rehabilitation.
- key: ng217
  text: >-
    National Institute for Health and Care Excellence. Epilepsies in children, young people and adults.
    NICE guideline NG217 (published 27 April 2022; last updated 5 August 2026).
  url: >-
    https://www.nice.org.uk/guidance/ng217/chapter/7-Treating-status-epilepticus-repeated-or-cluster-seizures-and-prolonged-seizures
  supports: >-
    7.1.1 Treat as status epilepticus seizures lasting 5 minutes or more. 7.1.2 Follow an individualised
    emergency management plan if immediately available. Give a benzodiazepine as first-line treatment
    in the community when no plan is available; if the first dose does not work, call emergency services
    (7.1.7-7.1.8). The robot never chooses or gives a medicine; this is context for the CMO and the onboard
    checklist.
- key: tb037
  text: >-
    NASA OCHMO. Decompression Sickness (DCS) Risk Mitigation. Technical Brief OCHMO-TB-037 Rev D (Oct
    5, 2026).
  url: https://www.nasa.gov/wp-content/uploads/2023/12/ochmo-tb-037-decompression-sickness.pdf
  supports: >-
    DCS is caused by inert gas bubbles forming during rapid reductions in ambient pressure, most significantly
    in the move from cabin pressure to EVA suit pressure; NASA classifies DCS as Type I (itching, musculoskeletal
    pain, mild rashes) and Type II (neurological symptoms, numbness, weakness, cognitive issues, inner
    ear problems, cardiopulmonary issues), and describes cutis marmorata (a mottled, patterned skin rash);
    arterial gas embolism can cause stroke-like neurological effects, loss of consciousness and seizures;
    U.S. Navy protocols are widely adopted on Earth; diagnosis is based on symptoms; the majority of cases
    present between 60 and 240 minutes and inflammatory responses can last more than 24 hours; no hyperbaric
    chamber is available in flight, and increasing suit and cabin pressure may be combined to treat symptoms,
    depending on the scenario; a break in prebreathe rapidly reintroduces nitrogen; NASA has never experienced
    a Type II event in spaceflight.
- key: nice150
  text: >-
    National Institute for Health and Care Excellence. Headaches in over 12s: diagnosis and management.
    Clinical guideline CG150.
  url: https://www.nice.org.uk/guidance/cg150/chapter/Recommendations
  supports: >-
    Headache features that need further investigation or referral include worsening headache with fever,
    sudden-onset headache reaching maximum intensity within 5 minutes, new-onset neurological deficit,
    and impaired level of consciousness.
- key: v1
  text: 'NASA. NASA-STD-3001, Space Flight Human-System Standard, Volume 1: Crew Health, Revision C (2023).'
  url: https://www.nasa.gov/wp-content/uploads/2023/11/nasa-std-3001-vol-1-rev-c-with-signature.pdf
  supports: 'NASA-STD-3001 Vol 1 Rev C: V1 3004, V1 3006, V1 3007.'
- key: v2
  text: >-
    NASA. NASA-STD-3001, Volume 2: Human Factors, Habitability, and Environmental Health (Rev F, 2026),
    including Section 10.6 Automated and Robotic Systems.
  url: https://standards.nasa.gov/standard/NASA/NASA-STD-3001_VOL_2
  supports: Requirement IDs beginning V2.
- key: tb044
  text: NASA OCHMO. Medical Operations. Technical Brief OCHMO-TB-044 (2025).
  url: https://www.nasa.gov/wp-content/uploads/2025/08/ochmo-tb-044-medical-operations.pdf
  supports: >-
    The crew surgeon keeps medical authority when care is delegated; crew medical officers train on the
    JSC 48522 medical checklist.
- key: marsdelay
  text: >-
    NASA. Mars communications disruption and delay (fact sheet, 2023 Moon to Mars Architecture Concept
    Review).
  url: https://www.nasa.gov/wp-content/uploads/2024/01/mars-communications-disruption-and-delay.pdf
  supports: >-
    One-way Earth-Mars delay up to about 21-23 minutes, plus blackouts of about 2-3 weeks near solar conjunction.
- key: pccp
  text: >-
    U.S. Food and Drug Administration. Marketing submission recommendations for a predetermined change
    control plan for artificial intelligence-enabled device software functions (guidance).
  url: >-
    https://www.fda.gov/regulatory-information/search-fda-guidance-documents/marketing-submission-recommendations-predetermined-change-control-plan-artificial-intelligence
  supports: A model for planning, validating and rolling back software updates.
- key: faa460
  text: 'U.S. Code of Federal Regulations, Title 14, Part 460: Human space flight requirements.'
  url: https://www.ecfr.gov/current/title-14/chapter-III/subchapter-C/part-460
  supports: >-
    Federal rules for crew and spaceflight participants on licensed commercial flights; they set no medical
    standards for spaceflight participants.
corrections:
- date: '2026-10-21'
  version: '0.2'
  source: >-
    AI-assisted clinical and source review by the Medical Research Assistant, Oct 21, 2026 (batch 5 review)
  items:
  - >-
    IN-1 and S2 record the time of onset, or if onset was not seen, the time last known well; both go
    in the flight surgeon package (item 9).
  - >-
    New input: current anticoagulant or antiplatelet medicine (including aspirin), as stated or from the
    medical record; the robot does not interpret bleeding risk and sends it privately with the FAST package
    (item 10).
  - >-
    Aspirin: the open question is closed. Any aspirin standing order lives only on the flight surgeon's
    checklist; without CT the risk judgment is the flight surgeon's alone; the robot never names aspirin
    or fetches it without a human order through RMP-PHARM-001 (item 11).
  - 'S6: the robot never says whether evacuation will happen (suggestion 34).'
  - >-
    Batch 5 drafts now record the review as AI-assisted (Medical Research Assistant, Oct 21, 2026); no
    named human clinician.
- date: '2026-10-21'
  version: '0.3'
  source: Batch 7 editorial (AI-assisted), Oct 21, 2026
  items:
  - >-
    Citation labels changed to the site's year-only convention: "(approved for public release <date>)"
    now reads "(YYYY)", and NASA-STD-3001 Volume 2 "Revision F (approved July 14, 2026)" now reads "(Rev
    F, 2026)" (sources: v2). Editorial; no change to steps, thresholds or limits.
  - >-
    X5 and the comms loss-of-signal branch now say only the robot pauses: crew oxygen, CPR and the CMO's
    checklist never wait for the link or the robot (batch 6 review item 24 / suggestion 40). Editorial;
    robot behaviour unchanged.
